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KMID : 0644120080210020076
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Journal of Oriental Gynecology
2008 Volume.21 No. 2 p.76 ~ p.96
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The Experimental Study on Anti-oxidant and Anti-inflammatory Effect of Jogantanggagambang(JGTG)
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Byun Hyung-Kuk
Yoo Dong-Youl
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Abstract
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Purpose: This study was performed to evaluate anti-inflammatory effects of Jogantanggagambang(JGTG).
Methods: In the study of anti-oxidant activities, JGTG was investigated by DPPH radical scavenger activity, superoxide dismutase activity and superoxide anion radical scavenger activity. In the study of anti-inflammatory effects, JGTG was investigated using cultured cells and murine models. As for the parameters of inflammation, levels of several inflammatory cytokines and chemical mediators which are known to be related to inflammation were measured in mouse lung fibroblast cells(mLFCs) and RAW264.7 cells.
Results:
1. JGTG showed a safety in cytotoxicity and toxicity of liver.
2. JGTG effected scavenging activity on DPPH free radical, superoxide dismutase and superoxide anion radical.
3. JGTG in RAW 264.7 cell decreased IL-1β mRNA expression, IL-6 mRNA expression, TNF-α mRNA expression at 50, 100 ㎍/㎖ and also decreased NOS-II mRNA expression at 100 ㎍/㎖, and decreased COX-2 mRNA expression at 10, 50, 100 ㎍/㎖.
4. JGTG in RAW 264.7 cell decreased significantly IL-1β, IL-6 and TNF-α at 50, 100 ㎍/㎖.
5. JGTG inhibited significantly IL-1β, IL-6 and TNF-α production in serum of acute inflammation-induced mice.
6. JGTG decreased significantly IL-1β mRNA production in spleen tissue.
Conclusion: These results suggest that JGTG can be used for treating diverse female diseases caused by inflammation.
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KEYWORD
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Jogantanggagambang, JGTG, superoxide anion radical, cytokine
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